Posted: 8 November 2026 - Chapel Hill, United States of America
The Postdoctoral Research Associate will support studies examining the role of the tumor-intrinsic NLRP3 inflammasome in immune evasion linked to tumor dormancy, treatment resistance, persistor cell development, tumor relapse, and metastatic progression. The role involves a combination of ex vivo tumor-T cell co-culture assays, in vivo tumor models, and analysis of tumor clinical specimens. Techniques include CRISPR/Cas9 gene deletion, cell purification, flow cytometry, Western blot, qRT-PCR, ELISA, RNAseq, scRNAseq, micro-CT imaging, IHC, FISH, proximity ligation assays, and spatial transcriptomics. The position is based at the UNC Lineberger Comprehensive Cancer Center, a leading cancer research institution.